ArticleWorld journal of gastrointestinal oncology2026
Relationship between preoperative modified frailty index, immune-inflammation index, and outcomes of colorectal cancer surgery in older patients.
Article in World journal of gastrointestinal oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundWith the aging of the population, the proportion of older patients with colorectal cancer (CRC) is increasing annually. Preoperative frailty and chronic inflammatory responses may increase the risk of postoperative complications and affect long-term survival.
aimTo assess modified frailty index (mFI) and systemic immune-inflammation index (SII) for predicting postoperative prognosis in older patients with CRC.
methodsWe retrospectively analyzed 247 older patients with CRC who underwent radical resection. The SII was calculated as platelet count × neutrophil count/lymphocyte count. Patients were grouped by complication occurrence. Univariate and multivariate analyses were performed for mFI, SII, and postoperative complications. Using receiver operating characteristic curve analysis, the critical SII value for predicting postoperative recurrence was identified, which was then used to divide patients into high/low mFI and high/low SII groups. Using Kaplan-Meier method between-group survival curves were drawn.
resultsThe 30-day complication rate was 12.55%. Multivariate logistic regression analysis identified smoking history [odds ratio (OR) = 4.822], prolonged operation time (OR = 1.037), and elevated preoperative mFI (OR = 9.342) and SII (OR = 1.002) as independent risk factors for postoperative complications (
conclusionIn older patients with CRC, the preoperative mFI and SII were significantly correlated with postoperative complications and RFS, warranting closer attention to early recurrence detection and intervention.
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