ArticleSpine surgery and related research2026
Efficacy of Chemonucleolysis with Condoliase for Lumbar Disc Herniation in Elderly Patients Over 70 Years of Age.
Article in Spine surgery and related research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The effectiveness of chemonucleolysis with condoliase for lumbar disc herniation in elderly patients over 70 years old.Neurosurgical review · 2026Article
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10 authors.
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Abstract
Introduction: Intradiscal therapy with condoliase is becoming one of the minimally invasive treatment options for lumbar disc herniation (LDH). However, evidence regarding its efficacy in elderly populations remains scarce. The purpose of this study is to reveal the efficacy of condoliase treatment for LDH in patients over the age of 70 years. Methods: The patients with LDH who received condoliase treatment in our institution with a follow-up period of 1 year were enrolled in this study. The patients were divided into two groups according to age: group E (>70 years) and group C (20-70 years). To assess clinical outcomes, visual analog scale (VAS) scores for leg and back pain and the Oswestry Disability Index (ODI) were obtained. Disc height and degeneration were evaluated using magnetic resonance imaging. Treatment was considered effective if the VAS scores for leg pain improved by ≥50% at 1 year and surgery was avoided. Results: A total of 121 patients were enrolled in the study. The therapy was effective in 12 of 17 patients (70.6%) in group E and 79 of 104 patients (76.0%) in group C. The deterioration rate of Pfirrmann grade was significantly higher in group C than in group E (53.9% vs. 7.1%). Improvements in VAS scores and ODIs were comparable between the two groups. There were no significant differences in disc height reduction or herniation reduction rates between the groups. Despite disc degeneration, herniation reduction was observed, accompanied by a decrease in disc height. Conclusions: Chemonucleolysis with condoliase is effective in treating LDH in patients over 70 years of age, affording outcomes comparable to those in younger patients. Despite disc degeneration, herniation reduction was observed accompanied by a decrease in disc height. Condoliase offers a less invasive alternative for treating elderly patients with multiple comorbidities. Careful patient selection is critical for ensuring optimal clinical results.
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