ArticleWorld journal of gastrointestinal surgery2026
Gallbladder small cell carcinoma from chronic cholecystitis: A case report and review of literature.
Article in World journal of gastrointestinal surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundChronic calculous cholecystitis (CCC), caused by persistent gallstone-induced inflammation, can lead to development of small cell neuroendocrine carcinoma (SCNEC) of the gallbladder through chronic irritation, cellular damage, and repair. This report describes a rare case of advanced SCNEC of the gallbladder potentially induced by CCC and highlights its clinical features and treatment challenges. CASE SUMMARY: A 64-year-old woman with a history of CCC presented with persistent right upper quadrant pain. Imaging revealed a mass in the gallbladder and hepatic hilum. The patient underwent radical cholecystectomy and hepatic resection. Histopathological examination confirmed SCNEC with synaptophysin and CD56 positivity and Ki-67 of 80%. Due to severe hepatic dysfunction (total bilirubin ≥ 300 μmol/L, albumin ≤ 25 g/L), chemotherapy was contraindicated. The patient's condition deteriorated rapidly, and she died 2 months postoperatively.
conclusionEarly detection and surgical intervention are critical for improving outcomes in gallbladder SCNEC associated with chronic inflammation.
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