ReviewFrontiers in neurology
Dose-response meta-analysis of plasma TMAO and stroke: validated linear risk threshold at 3.0 μmol/L.
Review in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Gut Microbiota and Ischemic Stroke: From Pre-Stroke Dysbiosis and Acute-Phase Changes to Therapeutic Applications.Brain and behavior · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Stroke, especially the ischemic type, remains a leading global cause of death and disability, with modifiable risk factors offering prevention opportunities. Trimethylamine N-oxide (TMAO), a gut-derived metabolite, promotes vascular damage and is linked to stroke risk. Although prior studies have explored dose-response relationships, clinically actionable thresholds remain undefined, limiting translational applications. This study aims to advance the field by quantifying a continuous dose-response relationship and determining a specific risk threshold, which is currently lacking, to inform preventive strategies. Methods: This PRISMA-compliant meta-analysis included 11 observational studies ( Results: Stroke patients showed significantly higher TMAO vs. controls (SMD = 0.55, 95% CI: 0.35, 0.74; Conclusion: TMAO exhibits a linear, dose-dependent association with stroke risk, with ≥ 3.0 μmol/L serving as a critical threshold for clinical intervention.
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