ArticleFrontiers in neurology
Analysis of comorbid characteristics, molecular mechanisms between mild cognitive impairment and Alzheimer's disease with interventions in a community-based population in Shanghai.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Mild cognitive impairment (MCI) is a critical early stage of Alzheimer's disease (AD). Elucidating the comorbidity characteristics, influencing factors, and molecular mechanisms between MCI and AD in community-based populations is crucial for early intervention in cognitive impairment. Methods: 2,234 elderly individuals aged 50 years or older from 14 communities in Pudong New District, Shanghai, were enrolled in this study. The Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), and Clinical Dementia Rating (CDR) were used to divide individuals into a control group ( Results: The prevalence of AD in the MCI group (30.17%) was significantly higher than that in the control group ( Conclusion: MCI patients in the community are at high risk of AD, and their comorbidity characteristics are affected by multidimensional lifestyle and psychological factors. Boldine and piceatannol may be potential natural compounds for the intervention of cognitive impairment. The results of this study can provide a theoretical basis for the early prevention and precise intervention of cognitive impairment in the community.
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