Integrating multi-omics insights into music and dance-based physical activity for cancer rehabilitation: implications for patient education and precision oncology.

Music and Dance-Based Physical Activity (MDPA) is an emerging, exercise-centered therapy that integrates artistic expression with structured physical movement, offering significant benefits for cancer rehabilitation. By combining dance with music therapy, MDPA enhances motor coordination, emotional regulation, and physiological resilience. Advances in multi-omics technologies, such as genomics, proteomics, and metabolomics, have provided valuable insights into the molecular mechanisms underlying these benefits, establishing a solid scientific foundation for its clinical application. MDPA modulates neuroendocrine function, inflammatory signaling, and metabolic reprogramming, promoting immune balance and neuroplasticity. Omics-based analyses further reveal the regulation of genes related to stress response, cellular remodeling, and mitochondrial metabolism in patients engaged in music and dance programs. These findings suggest that MDPA is a promising strategy for precision rehabilitation, with the potential to complement conventional cancer treatments. Importantly, integrating MDPA into patient education could enhance its impact, as patients become more informed about the molecular mechanisms at play and how MDPA can complement traditional therapies. Future research should focus on establishing clear links between molecular changes and clinical outcomes, validating MDPA through multicenter trials, and creating personalized implementation frameworks to integrate it effectively into routine oncology care.