ArticleFrontiers in human neuroscience2025
Lexicogrammatical profiling of ASD: cognitive-functional mapping and diagnostic implications.
Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Previous corpus-based study first established an annotated dataset of autism spectrum disorder (ASD) discourse, and subsequent modeling of lexicogrammatical patterns distinguished ASD from non-ASD discourse with high performance (accuracy 80%, precision 82%, sensitivity 73%, specificity 87%). That line of research further identified 46 statistically significant discriminators, of which 20 were analyzed in detail. The present study examines 18 additional discriminators and situates them within cognitive-functional domains to clarify their diagnostic relevance. Findings refine the language-cognition interface in ASD and extend the utility of lexicogrammatical profiling for assessment. Methods: The Tag Linear Model was employed to identify lexicogrammatical features that distinguish ASD and non-ASD discourse. Logistic regression with 10,000 bootstrap iterations was applied to establish statistical significance. Although DNN models yielded higher predictive accuracy, the linear model provided transparent identification of discriminators. Results: Of the 135 items analyzed, 46 were confirmed as statistically significant discriminators ( Discussion: These findings demonstrate that choice patterns of lexicogrammar in ASD reflect domain-specific cognitive constraints. Interpreting the 18 discriminators within 12 cognitive-functional domains provides a linguistically grounded perspective on the neurocognitive profile of ASD and offers implications for future diagnostic and intervention research.
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