ArticleMediators of inflammation2026
The Impact of White Blood Cell Count Trajectories on Prognosis and Secondary Acute Kidney Injury in Sepsis Patients.
Article in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Factors associated with postoperative respiratory failure in hospitalized patients with thoracolumbar fractures: a retrospective cross-sectional study based on the MIMIC-IV database.Journal of thoracic disease · 2026Article
- The Impact of White Blood Cell Count Trajectories on Prognosis and Secondary Acute Kidney Injury in Sepsis Patients.Mediators of inflammation · 2026Article
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Authors and funding
5 authors.
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Abstract
Background: Sepsis-associated acute kidney injury (SA-AKI) is a common and severe complication in critically ill patients, yet the prognostic value of longitudinal white blood cell (WBC) dynamics remains underexplored. Most studies rely on single-timepoint measurements, potentially overlooking important dynamic information for risk stratification. Objectives: This study aimed to identify distinct WBC trajectory patterns during the first 7 days of ICU admission and evaluate their associations with mortality and secondary AKI in sepsis patients. Methods: This retrospective cohort study analyzed 15,328 adult sepsis patients from the MIMIC-IV database (version 3.1) between 2008 and 2019. Group-based trajectory modeling (GBTM) was applied to daily WBC counts to identify trajectory subgroups. The primary outcome was 28-day mortality, with secondary outcomes including 90-day mortality and secondary AKI occurring after day 7. Cox proportional hazards regression was used to estimate hazard ratios with 95% confidence intervals. Subgroup analyses evaluated effect consistency across clinically relevant characteristics. Results: Four distinct WBC trajectory groups were identified: high ( Conclusions: Longitudinal WBC trajectory patterns provide superior prognostic information compared to single-timepoint measurements in sepsis patients, with persistently high WBC levels associated with increased mortality and secondary AKI risk.
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