Evidence map›Paper›PMID 41695594›Full record

ReviewExtracellular vesicles and circulating nucleic acids2026

80 years of extracellular vesicles: from discovery to clinical translation.

Qiang Li, Yinan Ding, Yejiao Shi, Chong Qiu, Lei Lei, Shenglong Li, Zheng Zhu, Judun Zheng, Cheng Qin, Kaiyuan Wang and 47 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Extracellular vesicles and circulating nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Exosome-mediated siRNA delivery in cancer: Loading strategies, targeting approaches, and therapeutic outcomes.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Extracellular vesicle-like particles fromFrontiers in pharmacology · 2026
    Article
  19. Crosstalk of extracellular vesicles in maternal-fetal interaction.Frontiers in cell and developmental biology · 2026
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

57 authors.

Qiang LiDepartment of Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.
Yinan DingZhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, Zhejiang, China.
Yejiao ShiInstitute of Translational Medicine, Shanghai University, Shanghai 200444, China.
Chong QiuArtemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Lei LeiMinistry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi'an 710069, Shaanxi, China.
Shenglong LiCancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, Liaoning, China.
Zheng ZhuDepartment of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi, China.
Judun ZhengDermatology Hospital, Southern Medical University, Guangzhou 510091, Guangdong, China.
Cheng QinPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Kaiyuan WangWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China.
Cheng JiangSchool of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, Guangdong, China.
Ziyi HanZhongda Hospital, Medical School of Southeast University, Nanjing 210009, Jiangsu, China.
Lingyan YangGuangzhou National Laboratory, Guangzhou 510005, Guangdong, China.
Lang ZhangInstitute of Rheumatology and Immunology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan, China.
Ping LiCheeloo College of Medicine, Shandong University, Qingdao 266237, Shandong, China.
Lingjun TongMedical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, Shandong, China.
Duan WangDepartment of Orthopedic Surgery and Orthopedic Research Institution, West China Hospital, Sichuan University, Chengdu 610041. Sichuan, China.
Hong XuDepartment of Orthopedic Surgery and Orthopedic Research Institution, West China Hospital, Sichuan University, Chengdu 610041. Sichuan, China.
Bingyang DaiDepartment of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Yangyang DuChangchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China.
Kaiyang WangDepartment of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Zhijin FanInstitute for Engineering Medicine, Kunming Medical University, Kunming 650500, Yunnan, China.
Wei WangInstitute for Engineering Medicine, Kunming Medical University, Kunming 650500, Yunnan, China.
Keying GuoDepartment of Biotechnology and Food Engineering, Guangdong Technology Israel Institute of Technology, Shantou 515063, Guangdong, China.
Yu HuangXinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Xia WangThe First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, Guangdong, China.
Bingdong SuiSchool of Stomatology, The Fourth Military Medical University, Xi'an 710032, Shaanxi, China.
Liang WenThe First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang, China.
Feixiong ChenFaculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu 90014, Finland.
Dechao FengDivision of Surgery & Interventional Science, University College London, London WC1E 6BT, UK.
Xiang QinSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, China.
Wenjun MaoWuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, Jiangsu, China.
Hongxing LiuThe First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, Guangdong, China.
Chen LiuTianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.
Zhaoting LiSchool of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, Guangdong, China.
Yongfei WangSchool of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, Guangdong, China.
Ru HuangSchool of Biomedical Engineering, Hainan University, Sanya 572025, Hainan, China.
Rong LuMarine College, Shandong University, Weihai 264209, Shandong, China.
Yulin ZhangCheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Ying TianMarine College, Shandong University, Weihai 264209, Shandong, China.
Xiaolong MiaoOrgan Transplantation Center, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China.
Yuan YinWuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi 214062, Jiangsu, China.
Jun ZhangDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Zhizeng WangDepartment of Laboratory Medicine, Chongqing Center for Clinical Laboratory, Chongqing Academy of Medical Sciences, Chongqing General Hospital, School of Medicine, Chongqing University, Chongqing 401147, China.
Teng MaDepartment of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT 84112, USA.
Haifeng DongSchool of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, Guangdong, China.
Daixu WeiClinical Medical College and Affiliated Hospital of Chengdu University, Chengdu University, Chengdu 610081, Sichuan, China.
Zhengyang YangBeijing friendship hospital, Capital medical university, Beijing 100050, China.
Xiaohong YangChongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China.
Xiaoyu ChengCollege of Optical Science and Engineering, Zhejiang University, Hangzhou 310052, Zhejiang, China.
Wojciech ChrzanowskiFaculty of Medicine and Health, The University of Sydney, Sydney 2006, Australia.
Zhigang ChangDepartment of Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.
Xudong ZhangSchool of Medicine, Sun Yat-sen University, Shenzhen 518107, Guangdong, China.
William C ChoDepartment of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR, China.
Yang LuoChongqing General Hospital, School of Medicine, Chongqing University, Chongqing 401147, China.
Weiliang XiaCenter for Aging and Cancer Research, Global Institute of Future Technology, Shanghai Jiao Tong University, Shanghai 200240, China.
Zhaohui HuangWuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi 214062, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are heterogeneous, lipid bilayer-enclosed vesicles secreted by cells. Research on EVs dates back to the 1940s, and the term "exosomes" - a major subtype of EVs - was coined in 1981 to describe small membrane vesicles shed from cells. However, it is only in the past two decades that research in this area has expanded rapidly. By transferring functional biomolecules, EVs play a pivotal role in intercellular communication and regulate a wide range of cellular functions under both physiological and pathological conditions. Owing to their high biocompatibility, capacity to protect encapsulated cargo from degradation, and ability to cross biological barriers, EVs also show great promise as biomarkers and drug-delivery systems. Following the first, albeit unintentional, isolation of EVs in 1946, the 80th anniversary of EV research is now approaching. In this review, we trace the history of EV research and summarize key advances in the field. We also discuss current challenges and future prospects in this rapidly evolving area.

Indexed as

apoptotic bodiesdrug deliveryexosomesExtracellular vesiclesintercellular communicationliquid biopsymicrovesicles

Identifiers

PMID41695594
PMCPMC12902917

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.