Evidence map›Paper›PMID 41695580›Full record

ArticleCurrent research in microbial sciences2026

Activation of the envelope stress-responsive two-component system AmgRS compensates for depletion of the essential lipoprotein signal peptidase LspA in

Davide Sposato, Giorgia Molesini, Christopher Riccardi, Jessica Mercolino, Luisa Torrini, Ilaria Varone, Manuela Cipolletti, Filippo Acconcia, Giordano Rampioni, Livia Leoni and 3 more

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Article in Current research in microbial sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Davide SposatoDepartment of Science, University Roma Tre, Rome, Italy.
Giorgia MolesiniDepartment of Science, University Roma Tre, Rome, Italy.
Christopher RiccardiDepartment of Biology, University of Florence, Florence, Italy.
Jessica MercolinoDepartment of Science, University Roma Tre, Rome, Italy.
Luisa TorriniDepartment of Science, University Roma Tre, Rome, Italy.
Ilaria VaroneDepartment of Science, University Roma Tre, Rome, Italy.
Manuela CipollettiDepartment of Science, University Roma Tre, Rome, Italy.
Filippo AcconciaDepartment of Science, University Roma Tre, Rome, Italy.
Giordano RampioniDepartment of Science, University Roma Tre, Rome, Italy.
Livia LeoniDepartment of Science, University Roma Tre, Rome, Italy.
Paolo ViscaDepartment of Science, University Roma Tre, Rome, Italy.
Marco FondiDepartment of Biology, University of Florence, Florence, Italy.
Francesco ImperiDepartment of Science, University Roma Tre, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial lipoproteins play crucial roles in cell envelope biogenesis, signaling, transport, and virulence, making the enzymes responsible for their maturation attractive targets for antibacterial drug development. Among these, the type II signal peptidase LspA is a particularly promising candidate, as several LspA inhibitors have been identified that exert potent antibacterial effects in some Gram-negative species. However, despite predictions that LspA is essential in

Indexed as

Cell envelopeHtpXLipoproteinsMembrane stressProteasesYccA

Identifiers

PMID41695580
PMCPMC12906115

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.