Evidence map›Paper›PMID 41695496›Full record

ArticleHeart rhythm O22026

Sex differences in procedural characteristics, safety, and clinical outcomes of pulsed field ablation for atrial fibrillation.

Fabian Jordan, Behnam Subin, Corinne Isenegger, Jonas Brügger, Jeanne du Fay de Lavallaz, Christine S Zuern, Emel Kaplan, David Spreen, Sven Knecht, Philipp Krisai and 7 more

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Article in Heart rhythm O2, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

17 authors.

Fabian JordanDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
Behnam SubinDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
Corinne IseneggerDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
Jonas BrüggerDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
Jeanne du Fay de LavallazDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
Christine S ZuernDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
Emel KaplanDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
David SpreenDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
Sven KnechtDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
Philipp KrisaiDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
Nicolas SchaerliDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
Beat SchärDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
Gian VöllminDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
Felix MahfoudDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
Christian SticherlingDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
Michael KühneDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
Patrick BadertscherDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Previous studies on pulmonary vein isolation (PVI) for the treatment of atrial fibrillation (AF) using conventional thermal techniques have shown inconsistent sex-related outcomes. Pulsed field ablation (PFA) is a novel energy source offering myocardial-selective ablation. However, sex-specific data on its performance are limited. Objective: This study aimed to compare procedural characteristics, safety, and clinical outcomes of PFA in female and male patients undergoing AF ablation. Methods: This prospective study included consecutive patients with paroxysmal or persistent AF undergoing PFA-based PVI using a pentaspline catheter. Follow-up was conducted at 3, 6, and 12 months. A 1:1 propensity score-matched cohort was created to evaluate sex-specific outcomes. Results: Among 425 patients, 134 (32%) were women. Compared with men, women were older (median 70 vs 65 years; Conclusion: Significant sex-related differences exist in clinical outcomes after PVI with PFA in AF. Further studies exploring underlying mechanisms and tailored approaches may enhance outcomes in female patients.

Indexed as

1-year follow-upAtrial fibrillationComplicationsOutcomesProcedural characteristicsPulmonary vein isolationPulsed field ablationSex differences

Identifiers

PMID41695496
PMCPMC12902224

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.