Evidence map›Paper›PMID 41695488›Full record

ArticleTheranostics2026

Modeling immunotherapies in live 3D human cancer tissue bioreactors.

Yizheng Zhang, Ivan Foth, Ahmad Makky, Philip Bucher, Melanie Grimm, Peter-Martin Bruch, Ilona Hagelstein, Sascha Dietrich, Josef Leibold, Lukas Flatz and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yizheng ZhangDepartment of Pathology and Neuropathology, University Hospital and Comprehensive Cancer Center Tübingen, Germany.
Ivan FothDepartment of Pathology and Neuropathology, University Hospital and Comprehensive Cancer Center Tübingen, Germany.
Ahmad MakkyDepartment of Pathology and Neuropathology, University Hospital and Comprehensive Cancer Center Tübingen, Germany.
Philip BucherCluster of Excellence iFIT (EXC 2180) "Image-guided and Functionally Instructed Tumor Therapies", University of Tübingen, Germany.
Melanie GrimmCluster of Excellence iFIT (EXC 2180) "Image-guided and Functionally Instructed Tumor Therapies", University of Tübingen, Germany.
Peter-Martin BruchDepartment of Hematology, Oncology and Clinical Immunology, University Hospital Düsseldorf, Germany.
Ilona HagelsteinCluster of Excellence iFIT (EXC 2180) "Image-guided and Functionally Instructed Tumor Therapies", University of Tübingen, Germany.
Sascha DietrichDepartment of Hematology, Oncology and Clinical Immunology, University Hospital Düsseldorf, Germany.
Josef LeiboldCluster of Excellence iFIT (EXC 2180) "Image-guided and Functionally Instructed Tumor Therapies", University of Tübingen, Germany.
Lukas FlatzDepartment of Dermatology, University Hospital and Comprehensive Cancer Center Tübingen, Germany.
Judith FeuchtCluster of Excellence iFIT (EXC 2180) "Image-guided and Functionally Instructed Tumor Therapies", University of Tübingen, Germany.
Sven BeckerDepartment of Otorhinolaryngology, Head & Neck Surgery, University Hospital and Comprehensive Cancer Center Tübingen, Germany.
Christian M SchürchDepartment of Pathology and Neuropathology, University Hospital and Comprehensive Cancer Center Tübingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BioreactorsImmunotherapyImmunotherapy, AdoptiveNeoplasmsTissue Culture TechniquesCell Line, TumorHumansLymph NodesT-LymphocytesTumor Microenvironment3D tissue cultureCAR T cellsCODEX multiplexed fluorescence microscopy.immune checkpoint inhibitorperfusion bioreactor

Identifiers

PMID41695488
PMCPMC12905668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.