Evidence map›Paper›PMID 41695477›Full record

ArticleTheranostics2026

NPM1 phosphorylation-mediated telomere maintenance via stabilization of POLD3 in ALT-positive osteosarcoma: unraveling mechanisms and therapeutic opportunities.

Rui Zhao, Tingfang Li, Qiuhui Yang, Duo Jiang, Yanan Xue, Haomeng Kou, Qianqian Wang, Yuwen Wang, Xinyu Han, Wenbin Ma and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Rui ZhaoDepartment of Genetics, School of Basic Medical Science, Tianjin Medical University, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Institute of Prosthodontics School and Hospital of Stomatology, Tianjin Medical University General Hospital, Tianjin, PR China.
Tingfang LiDepartment of Genetics, School of Basic Medical Science, Tianjin Medical University, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Institute of Prosthodontics School and Hospital of Stomatology, Tianjin Medical University General Hospital, Tianjin, PR China.
Qiuhui YangDepartment of Genetics, School of Basic Medical Science, Tianjin Medical University, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Institute of Prosthodontics School and Hospital of Stomatology, Tianjin Medical University General Hospital, Tianjin, PR China.
Duo JiangDepartment of Genetics, School of Basic Medical Science, Tianjin Medical University, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Institute of Prosthodontics School and Hospital of Stomatology, Tianjin Medical University General Hospital, Tianjin, PR China.
Yanan XueDepartment of Genetics, School of Basic Medical Science, Tianjin Medical University, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Institute of Prosthodontics School and Hospital of Stomatology, Tianjin Medical University General Hospital, Tianjin, PR China.
Haomeng KouDepartment of Genetics, School of Basic Medical Science, Tianjin Medical University, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Institute of Prosthodontics School and Hospital of Stomatology, Tianjin Medical University General Hospital, Tianjin, PR China.
Qianqian WangDepartment of Genetics, School of Basic Medical Science, Tianjin Medical University, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Institute of Prosthodontics School and Hospital of Stomatology, Tianjin Medical University General Hospital, Tianjin, PR China.
Yuwen WangDepartment of Genetics, School of Basic Medical Science, Tianjin Medical University, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Institute of Prosthodontics School and Hospital of Stomatology, Tianjin Medical University General Hospital, Tianjin, PR China.
Xinyu HanDepartment of Genetics, School of Basic Medical Science, Tianjin Medical University, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Institute of Prosthodontics School and Hospital of Stomatology, Tianjin Medical University General Hospital, Tianjin, PR China.
Wenbin MaDepartment of Biochemistry, State Key Laboratory of Biocontrol, Sun Yat-sen University, Guangzhou, PR China.
Guowen WangDepartment of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, PR China.
Jinyan FengDepartment of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, PR China.
Xiuxin HanDepartment of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, PR China.
Yancheng LiuDepartment of Spinal Surgery, Tianjin Hospital, Tianjin, PR China.
Yaqing JingDepartment of Genetics, School of Basic Medical Science, Tianjin Medical University, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Institute of Prosthodontics School and Hospital of Stomatology, Tianjin Medical University General Hospital, Tianjin, PR China.
Xin GengDepartment of Biochemistry and Molecular Biology, School of Basic Medical Science, Tianjin Medical University, Tianjin, PR China.
Fei WangDepartment of Neurology, Tianjin Medical University General Hospital, Tianjin, PR China.
Yang LiuState Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, PR China.
Qiang ZhangDepartment of Geriatrics, Tianjin Medical University General Hospital, Tianjin Geriatrics Institute, Tianjin, PR China.
Feng WangDepartment of Genetics, School of Basic Medical Science, Tianjin Medical University, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Institute of Prosthodontics School and Hospital of Stomatology, Tianjin Medical University General Hospital, Tianjin, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maintaining telomere integrity is essential for cellular survival, and reactivation of telomerase or alternative lengthening of telomeres (ALT) represents a hallmark of cancer, ensuring replicative immortality. Osteosarcoma (OS), a malignancy in which many tumors rely on ALT for telomere maintenance, lacks effective therapeutic strategies targeting this pathway. This study aimed to identify and characterize novel molecular regulators of ALT activity and explore their potential as therapeutic targets in OS.

Indexed as

Bone NeoplasmsNuclear ProteinsOsteosarcomaTelomereTelomere HomeostasisAnimalsCell Line, TumorCell ProliferationDoxorubicinFemaleHumansMaleMiceMice, NudeNucleophosminPhosphorylationDoxorubicinNPM1 protein, humanNpm1 protein, mouseNuclear ProteinsNucleophosminALTBITRCSTNPM1POLD3telomere

Identifiers

PMID41695477
PMCPMC12905828

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.