Evidence map›Paper›PMID 41695476›Full record

ArticleTheranostics2026

Hyperglycemia in combination with excess fat intake promotes renal pyroptosis and fibrosis through Gα

Muhammad Sohaib Khan, Boram Kim, Yerim Jeon, Jihoon Tak, Yun Seok Kim, Sang Gil Lee, Eun Byul Lee, Chang-Hoon Lee, Cheol Bin Eom, Hyun Sook Lee and 6 more

Abstract read
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Muhammad Sohaib KhanCollege of Pharmacy, Dongguk University, Goyang-si, Kyeonggi-do 10326, Republic of Korea.
Boram KimCollege of Pharmacy, Dongguk University, Goyang-si, Kyeonggi-do 10326, Republic of Korea.
Yerim JeonCollege of Pharmacy, Dongguk University, Goyang-si, Kyeonggi-do 10326, Republic of Korea.
Jihoon TakCollege of Pharmacy, Dongguk University, Goyang-si, Kyeonggi-do 10326, Republic of Korea.
Yun Seok KimCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Korea.
Sang Gil LeeCenter of Research and Development, A Pharma Inc, Goyang-si, Gyeonggi-do, Republic of Korea.
Eun Byul LeeCenter of Research and Development, A Pharma Inc, Goyang-si, Gyeonggi-do, Republic of Korea.
Chang-Hoon LeeBK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University, Seoul 04620, Republic of Korea.
Cheol Bin EomSchool of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, 06419, Republic of Korea.
Hyun Sook LeeDepartment of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, #88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea.
Hyeon-Ki JangKangwon National University, Chuncheon 24341, South Korea.
Nakyeom LeeCollege of Pharmacy, Dongguk University, Goyang-si, Kyeonggi-do 10326, Republic of Korea.
Jeong Hae KieDepartment of Pathology, NHIS Ilsan Hospital, Goyang, Gyeonggi-do, 10444, Republic of Korea.
Jee Myung YangDepartment of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, #88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea.
Yoon Mee YangSchool of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, 06419, Republic of Korea.
Sang Geon KimCollege of Pharmacy, Dongguk University, Goyang-si, Kyeonggi-do 10326, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Endoplasmic Reticulum StressHyperglycemiaKidneyPyroptosisAnimalsDiet, High-FatEndoplasmic Reticulum Chaperone BiPFibrosisHEK293 CellsHumansMaleMiceMice, Inbred C57BLSignal TransductionStreptozocinEndoplasmic Reticulum Chaperone BiPHSPA5 protein, humanHspa5 protein, mouseStreptozocinER stressfibrosisfree fatty acidshuman kidneyhyperglycemiarenal pyroptosis

Identifiers

PMID41695476
PMCPMC12905788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.