Evidence map›Paper›PMID 41695468›Full record

ArticleTheranostics2026

Myeloid cell-specific β2-adrenergic receptor deletion improves early cardiac injury resolution via de-repression of Anxa1.

Tapas K Nayak, Anamika Bajpai, Viren Patwa, Rhonda L Carter, Nitya Enjamuri, Erhe Gao, Sudarsan Rajan, Yang K Xiang, Douglas G Tilley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Tapas K NayakAging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA, 19140.
Anamika BajpaiAging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA, 19140.
Viren PatwaAging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA, 19140.
Rhonda L CarterAging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA, 19140.
Nitya EnjamuriAging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA, 19140.
Erhe GaoAging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA, 19140.
Sudarsan RajanAging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA, 19140.
Yang K XiangDepartment of Medicine, University of California at Los Angeles, CA, USA, 90095.
Douglas G TilleyAging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA, 19140.

Funding

Small and large animal surgery, physiology and histologyP01HL134608 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI Raj Kishore · 2017 to 2026
$21.0M
Targeting Pathways Involved in Cardiac Injury for Novel Repair StrategiesP01HL147841 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KOCH, WALTER J. · 2020 to 2024
$11.4M
Regulation of a cardiac b1AR/SERCA2 complex in heart failureR01HL162825 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI XIANG, YANG KEVIN · 2022 to 2025
$2.5M
Beta adrenergic receptor-dependent regulation of leukocytes in acute cardiac injuryR01HL139522 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI TILLEY, DOUGLAS · 2018 to 2021
$2.0M
Molecular Regulation of cardiac adrenergic signalingR01HL147263 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI XIANG, YANG K · 2019 to 2022
$1.7M
BLRD VA I01 BX005100BLRD VA IK6 BX005753NHLBI NIH HHS P01 HL134608NHLBI NIH HHS P01 HL147841NHLBI NIH HHS R01 HL139522NHLBI NIH HHS R01 HL147263NHLBI NIH HHS R01 HL162825
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Annexin A1Myeloid CellsMyocardial InfarctionReceptors, Adrenergic, beta-2AnimalsDisease Models, AnimalEfferocytosisGene DeletionMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutMicroRNAsNeutrophilsAnnexin A1annexin A1, mouseMicroRNAsReceptors, Adrenergic, beta-2

Identifiers

PMID41695468
PMCPMC12905670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.