Evidence map›Paper›PMID 41695416›Full record

ArticleRSC advances2026

Dual-targeting sulfamethoxazole derivatives overcome multidrug resistance in ESKAPE pathogens by inhibiting quorum sensing and efflux pumps.

Benedicta Yayra Adzah, Prince Danan Biniyam, Victoria Ohene-Adu, Michael Osei, Kwabena Adu-Adjei, Victoria Elmes, Iain Goodall, Vuvor Faustina, Yvonne Dogbeda Agboyibor, Patrick Gyan and 7 more

Abstract read
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In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Benedicta Yayra AdzahDepartment of Pharmaceutical Chemistry, Drug Discovery Unit, School of Pharmacy, University of Health and Allied Sciences Ho Ghana camengor@uhas.edu.gh +233246456764.
Prince Danan BiniyamDepartment of Pharmaceutical Chemistry, Drug Discovery Unit, School of Pharmacy, University of Health and Allied Sciences Ho Ghana camengor@uhas.edu.gh +233246456764.
Victoria Ohene-AduDepartment of Pharmaceutical Chemistry, Drug Discovery Unit, School of Pharmacy, University of Health and Allied Sciences Ho Ghana camengor@uhas.edu.gh +233246456764.
Michael OseiDepartment of Pharmaceutical Chemistry, Drug Discovery Unit, School of Pharmacy, University of Health and Allied Sciences Ho Ghana camengor@uhas.edu.gh +233246456764.
Kwabena Adu-AdjeiDepartment of Pharmaceutical Chemistry, Drug Discovery Unit, School of Pharmacy, University of Health and Allied Sciences Ho Ghana camengor@uhas.edu.gh +233246456764.ORCID https://orcid.org/0009-0005-2593-8817
Victoria ElmesSchool of Science, University of Greenwich UK.
Iain GoodallSchool of Science, University of Greenwich UK.
Vuvor FaustinaDepartment of Pharmaceutical Chemistry, Drug Discovery Unit, School of Pharmacy, University of Health and Allied Sciences Ho Ghana camengor@uhas.edu.gh +233246456764.
Yvonne Dogbeda AgboyiborDepartment of Pharmaceutical Chemistry, Drug Discovery Unit, School of Pharmacy, University of Health and Allied Sciences Ho Ghana camengor@uhas.edu.gh +233246456764.
Patrick GyanDepartment of Pharmaceutical Chemistry, Drug Discovery Unit, School of Pharmacy, University of Health and Allied Sciences Ho Ghana camengor@uhas.edu.gh +233246456764.ORCID https://orcid.org/0000-0002-3304-0928
Paul QuansahDepartment of Pharmaceutical Chemistry, Drug Discovery Unit, School of Pharmacy, University of Health and Allied Sciences Ho Ghana camengor@uhas.edu.gh +233246456764.
Cyril Makafui AmengorDepartment of Mathematics, University of Ghana Legon Ghana.
Joshua BoatengSchool of Science, University of Greenwich UK.ORCID https://orcid.org/0000-0002-6310-729X
En ZhangSchool of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University Zhengzhou 450001 PR China.ORCID https://orcid.org/0000-0002-4818-756X
Maxwell Ampomah-WirekoSchool of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University Zhengzhou 450001 PR China.
Ernest OyehDepartment of Nursing, Faculty of Science, Methodist University Ghana Ghana.
Cedric Dzidzor Kodjo AmengorDepartment of Pharmaceutical Chemistry, Drug Discovery Unit, School of Pharmacy, University of Health and Allied Sciences Ho Ghana camengor@uhas.edu.gh +233246456764.ORCID https://orcid.org/0000-0003-2913-446X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapid emergence of pan-drug-resistant pathogens necessitates innovative antimicrobial strategies that overcome conventional resistance. This study reports the structure-guided design of sulfamethoxazole derivatives as dual inhibitors of quorum sensing (LasR) and efflux pumps (AcrB), alongside the classic dihydropteroate synthase (DHPS) target. High-throughput virtual screening of 54 derivatives, followed by MM-GBSA analysis, prioritized five novel compounds for synthesis. Their structures were confirmed by

Identifiers

PMID41695416
PMCPMC12903755

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.