ReviewFrontiers in cell and developmental biology2026
Cellular plasticity: a double-edged sword driving malignant transformation and adaptive remodeling in stem cells.
Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Tumor cell plasticity in non-small cell lung cancer: the role of microRNA and implications for diagnosis, prognosis and treatment.Translational cancer research · 2026Review
- Radiomic analysis of the peritumoral zone identifies imaging signatures of glioma invasion associated with HSP70 expression.Frontiers in oncology · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review systematically examines the dual roles of cellular plasticity in stem cell biology. Stem cells leverage their inherent plasticity to achieve adaptive tissue remodeling, including migration, differentiation, and microenvironment interactions during development, regeneration, and homeostasis maintenance. However, this property can also be hijacked by cancer cells, particularly cancer stem cells, as a key mechanism for malignant transformation, invasion, metastasis, and therapeutic resistance. This review will delve into the molecular foundations of cellular plasticity, such as cytoskeletal dynamics, nuclear plasticity, and cell junctional plasticity, analyzing the regulatory similarities and differences between physiological remodeling and pathological transformation. Finally, we will explore the potential and challenges of targeting cellular plasticity as a novel anti-cancer strategy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.