ArticleCase reports in dentistry2026
Cross-Linked Hyaluronic Acid and Laser Photobiomodulation in Guided Bone Regeneration (GBR): A Case Report Describing a New Combined Technique.
Article in Case reports in dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Cross-Linked Hyaluronic Acid and Laser Photobiomodulation in Guided Bone Regeneration (GBR): A Case Report Describing a New Combined Technique.Case reports in dentistry · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perfect maintenance of the soft tissue and bone level at the implant site substantially influences the long-term surgical success and esthetic and functional results of prosthetic rehabilitation. Hyaluronic acid (HA) is a glycosaminoglycan, that is a long linear polymer chain formed by the repetition of disaccharide units, in turn composed of alternating molecules of glucuronic acid and N-acetylglucosamine joined together by glycosidic and hydrogen bonds. HA in oral surgery improves wound healing by stimulating clot formation, inducing angiogenesis, increasing osteogenesis, preserving the viability of periodontal ligament fibroblasts and gingival fibroblasts, and accelerating bone regeneration through chemotaxis, proliferation, and subsequent differentiation of mesenchymal cells. The cross-linking process, which modifies the three-dimensional structure of the HA chains, gives the product a higher molecular weight and, consequently, a greater density, slower reabsorption, and longer lasting action. Laser photobiomodulation (laser PBMT) promotes wound healing by inducing cell proliferation, anti-inflammatory responses, pain relief, and scar formation inhibition. The present paper describes the clinical case of a 72-year-old male patient who, due to a large vestibular bone defect in Zone 1.1, required bone regeneration. The aim of this case report was to propose a combination of cross-linked hyaluronic acid (xHyA) and laser PBMT to support bone and soft tissue regeneration in areas of severe periodontal compromise and tissue defects.
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