ArticleFrontiers in oncology2026
Case Report: A case of Lynch syndrome-related glioblastoma with coexisting
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This case report describes a 38-year-old Chinese male with Lynch syndrome (LS)-associated glioblastoma (GBM), harboring concurrent germline NM_000251.3:c.942 + 3A>T and somatic NM_000179.3:c.3261dup mutations. The patient presented with progressive headaches, and imaging revealed a right frontal lobe mass with features suggestive of high-grade glioma. Histopathological and molecular analyses confirmed glioblastoma (WHO grade IV), microsatellite instability-high (MSI-H), and mismatch repair deficiency (dMMR). Familial cancer history, including colorectal and gallbladder malignancies in first-degree relatives, aligned with LS diagnostic criteria. The co-occurrence of
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