ReviewDrugs in context2026
Ustekinumab-associated morphoea: systematic review of the literature and a real-world case.
Review in Drugs in context, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
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Abstract
Ustekinumab, an IL-12/IL-23 inhibitor with an established safety profile, has recently been associated with paradoxical cutaneous immune reactions. Amongst these, morphoea developing during therapy represents a rare but mechanistically relevant phenomenon that highlights cytokine imbalance in skin homeostasis. We performed a systematic review of published cases of morphoea occurring in patients treated with ustekinumab to better define their clinical and therapeutic patterns, and coupled it to the description of a new case of morphoea in a patient receiving ustekinumab for Behçet disease. A search of PubMed, Web of Science and SciELO through October 2025 identified six eligible reports. Patients (median age 55.5 years) received ustekinumab for psoriasis, psoriatic arthritis or inflammatory bowel disease. Morphoea developed after 6-64 months of treatment and presented exclusively as plaque-type lesions with one showing overlap with lichen sclerosus. Discontinuation of ustekinumab led to improvement or remission in most patients, whilst continued therapy was associated with progression in one case. The temporal pattern, morphology and response to withdrawal support a drug-related effect, potentially reflecting a shift from a T helper 1 (T
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