ReviewDrugs in context2026
Emerging concepts in HIV pre-exposure prophylaxis: focus on twice-yearly lenacapavir.
Review in Drugs in context, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The persistent global burden of HIV and the need for more flexible, durable prevention strategies have accelerated the development of long-acting pre-exposure prophylaxis (PrEP) options. Lenacapavir (LEN), a first-in-class capsid inhibitor, is approved as a twice-yearly subcutaneous injection for HIV prevention and represents a major advance beyond oral injectable PrEP regimens administered daily or every 2 months. Data from phase III trials demonstrate high efficacy, sustained drug levels and strong adherence potential, positioning LEN as a transformative option for individuals seeking long-acting protection. Its unique mechanism of action and extended dosing interval can address key barriers to PrEP uptake and persistence, particularly amongst populations disproportionately at risk for HIV. LEN may play a central role in expanding choice and improving the real-world effectiveness of PrEP. Ongoing considerations include implementation logistics, equitable access, potential drug resistance and integration into existing prevention frameworks. Twice-yearly LEN is a critical addition to the evolution of HIV prevention strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.