Evidence map›Paper›PMID 41695196›Full record

ArticleStem cells international2026

Evaluation of the Osteogenic Potential of Apigenin via Inducing Autophagy: An In Vitro Study.

Mozafar Khazaei, Amirmohammad Khodaei, Maryam Bozorgi, Mohammad Rasool Khazaei, Azam Bozorgi

Abstract read
In one paragraph

Article in Stem cells international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mozafar KhazaeiFertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran, kums.ac.ir.ORCID https://orcid.org/0000-0003-0536-3217
Amirmohammad KhodaeiStudent Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran, kums.ac.ir.ORCID https://orcid.org/0009-0009-1077-7861
Maryam BozorgiFertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran, kums.ac.ir.ORCID https://orcid.org/0000-0003-4381-6715
Mohammad Rasool KhazaeiFertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran, kums.ac.ir.ORCID https://orcid.org/0000-0001-9818-0625
Azam BozorgiFertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran, kums.ac.ir.ORCID https://orcid.org/0000-0003-3274-6125

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aimed to evaluate the effect of apigenin (Api) on the osteogenic differentiation of adipose tissue-derived mesenchymal stem cells (ASCs) by stimulating autophagy. ASCs were isolated from fresh adipose tissues using mechanical and enzymatic digestion and characterized using flow cytometry. ASCs were treated with Api (0, 5, 10, 25, and 50 µM) for 48 and 72 h. After determining the optimal doses of Api (5 and 10 µM), ASCs were differentiated into the osteogenic lineage for 7 and 21 days. The expression of osteogenic and autophagy genes and proteins, as well as alkaline phosphatase (

Indexed as

apigeninautophagymesenchymal stem cellsosteogenic differentiation

Identifiers

PMID41695196
PMCPMC12901651

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.