An unusual trilogy: a case of comorbid aHUS, Fabry disease, and hypertrophic cardiomyopathy.

Qian Li, Lichun Yu, Jing Wang, Zhenle Yang, Yanhua Duan, Junhui Zhen, Shuzhen Sun

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In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Qian LiDepartment of Pediatric Nephrology and Rheumatism and Immunology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

Lichun YuDepartment of Pediatric Nephrology and Rheumatism and Immunology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

Jing WangDepartment of Pediatric Nephrology and Rheumatism and Immunology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

Zhenle YangDepartment of Pediatric Nephrology and Rheumatism and Immunology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

Yanhua DuanDepartment of Nuclear Medicine, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.

Junhui ZhenDepartment of Pathology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.

Shuzhen SunDepartment of Pediatric Nephrology and Rheumatism and Immunology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 7-year-old boy was admitted to the hospital for abdominal pain, vomiting, and edema. Examinations revealed microvascular hemolytic anemia, thrombocytopenia, acute kidney injury, and hypocomplementemia. He was diagnosed with atypical hemolytic uremic syndrome (aHUS), and treatment was initiated with a methylprednisolone pulse, followed by cyclophosphamide, mycophenolate mofetil, and fresh frozen plasma infusion, leading to remission. At the age of 12, he developed numbness in his fingers and pain in his toes while being febrile. At the age of 17, he presented with aggravated toe pain, renal impairment (creatinine concentration of 156 μmol/L; eGFR of 38.4 mL/min/1.73 m

Indexed as

atypical hemolytic uremic syndromechronic kidney diseaseFabry diseasehypertensionhypertrophic cardiomyopathy

Identifiers

PMID41695170

DOI10.3389/fmed.2026.1700541

PMCPMC12900690

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