ArticleFrontiers in medicine2026
Efficacy and safety of Ixazomib-based maintenance therapy after autologous hematopoietic stem cell transplantation in multiple myeloma patients: a retrospective analysis.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The therapeutic standard for post-autologous stem cell transplantation (ASCT) maintenance in multiple myeloma (MM) is evolving, with daratumumab-based regimens emerging as highly effective. However, access to such therapies remains limited in regions like China. This study evaluated the real-world efficacy and safety of the oral proteasome inhibitor ixazomib as a practical alternative for maintenance therapy in this setting. Methods: This single-center, retrospective analysis included 28 MM patients who received ixazomib-based maintenance (monotherapy or combination) for ≥5 months after ASCT (from a total cohort of 64 ASCT recipients) between August 2019 and August 2023. Treatment was assigned based on mSMART 3.0 risk stratification and adjusted per clinical circumstances. The primary endpoint was progression-free survival (PFS). Secondary endpoints included treatment response, minimal residual disease (MRD) status, and safety. Results: The median age of the patients was 57 years (range: 48-69). Before ASCT, 9 patients (32.1%) achieved complete response (CR), 7 (25.0%) achieved very good partial response (VGPR), and 12 (42.9%) achieved partial response (PR). After ASCT, responses deepened: 17 patients (60.7%) achieved CR, 6 (21.4%) VGPR, and 5 (17.9%) PR. Following Ixazomib maintenance, 15 patients (53.5%) were in CR, 8 (28.6%) in VGPR, and 5 (17.9%) in PR. Four patients experienced disease progression during follow-up. The incidence of grade ≥ 3 adverse events was 3.6%. The estimated 3-year PFS and overall survival rates were 70.8% (95% CI, 52.18%-89.42%) and 87.4% (95% CI, 73.88%-100.92%), respectively. Notably, patients who sustained MRD negativity for over 1 year had an estimated 3-year PFS of 100%, significantly higher than that of MRD-positive patients. Discussion: Within the constraints of the current Chinese clinical context, ixazomib-based maintenance therapy demonstrates favorable efficacy and a manageable safety profile for MM patients after ASCT, offering a viable and accessible alternative. Achieving sustained MRD negativity is critically important for long-term outcomes, reinforcing its value as a key treatment goal. These real-world findings support the role of ixazomib, particularly for patients ineligible for or intolerant to standard regimens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.