ArticleFrontiers in medicine2026
A novel immune model predicts the prognosis of mantle cell lymphoma.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Corrections and comments
- Erratum issued
Authors and funding
8 authors.
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Abstract
Background: Mantle Cell Lymphoma (MCL) is a subtype of B-cell lymphoma characterized by varied clinical manifestations. The immune status is associated with MCL's development and outcome. This study aims to evaluate the prognostic value of peripheral cytokines and blood lymphocyte subsets in MCL patients. Methods: This retrospective study analyzed patients' clinical characteristics, treatment strategies, progression-free survival (PFS), and overall survival (OS). Immune cell levels and cytokines were evaluated via peripheral blood flow cytometry. Prognostic models incorporating immune characteristics were developed using XGBoost algorithms. Results: The study involved 78 MCL patients with a median follow-up period of 40 months. The median PFS and median OS were 32 and 48 months. Univariate analysis linked poor PFS to factors including elevated β2-MG, Ann Arbor stage III-IV, low albumin levels (<35 g/L), high SUVmax (≥11), reduced T cells (<70.42%), reduced CD4 + T cells (<34.63%), and increased NK cells (≥8.37%). Factors linked to poor OS included the pleomorphic and blastoid subtypes, albumin below 35 g/L, and high SUVmax (≥11). Multivariate analysis identified high SUVmax (≥11) as an independent predictor of poor PFS and OS in MCL patients. XGBoost regression and classification models were developed to determine feature importance, highlighting five key features: SUVmax, LDH, IL-2, TNF- Conclusion: This study developed an innovative immune prognostic model for evaluating the prognosis of MCL patients, integrating immune factors with existing clinical features to improve prognostic evaluation.
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