ArticleReproductive medicine and biology
Caffeine Supplementation Enhances Aged Human Oocyte Quality and Embryo Development in In Vitro Fertilization: A Retrospective Paired Study.
Article in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Antioxidant Supplementation with Caffeine During Rescue In Vitro Maturation Improves Fertilization and Embryo Development in Women of Advanced Maternal Age.Antioxidants (Basel, Switzerland) · 2026Article
- Caffeine Supplementation Enhances Aged Human Oocyte Quality and Embryo Development in In Vitro Fertilization: A Retrospective Paired Study.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To evaluate whether in vitro caffeine supplementation can improve spindle integrity, embryo development, and clinical outcomes in IVF. Methods: This retrospective paired-cohort study included 704 women aged ≥ 35 years who underwent two ICSI cycles (one caffeine-supplemented and one non-caffeine) within 12 months. Oocytes in caffeine cycles were exposed to 1.25 mM caffeine for 4 h before fertilization. Outcomes included spindle positioning, embryo quality, blastocyst development and euploidy rates, and neonatal outcomes from 20 women (24 neonates). Paired comparisons were performed using the Wilcoxon signed-rank and McNemar's tests. Results: Caffeine cycles showed higher rates of normal spindle positioning (80.2% vs. 61.2%, Conclusions: Short-term in vitro caffeine exposure may enhance oocyte and embryo competence in older women undergoing IVF, especially those with prior IVF failures. These findings support caffeine as a simple, practical laboratory intervention. Prospective multicenter studies are warranted to confirm efficacy and safety.
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