Evidence map›Paper›PMID 41695020›Full record

ArticleACS nano medicine2026

A Membrane Fluidization Strategy Significantly Boosts Photodynamic Therapy and Antitumor Immunity of Porphyrin-Lipid Nanoparticles.

Tiffany Ho, Michael Valic, Tracy W Liu, Mark Zheng, Yiming Yang, Keegan Guidolin, Lili Ding, Yulin Mo, Ashley Qian, Nahyun Kwon and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tiffany HoPrincess Margaret Cancer Centre, University Health Network, 101 College Street, PMCRT 5-354, Toronto, ON M5G1L7, Canada.
Michael ValicPrincess Margaret Cancer Centre, University Health Network, 101 College Street, PMCRT 5-354, Toronto, ON M5G1L7, Canada.
Tracy W LiuDepartment of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, West Virginia 26506, United States.ORCID https://orcid.org/0000-0003-0671-8390
Mark ZhengPrincess Margaret Cancer Centre, University Health Network, 101 College Street, PMCRT 5-354, Toronto, ON M5G1L7, Canada.
Yiming YangPrincess Margaret Cancer Centre, University Health Network, 101 College Street, PMCRT 5-354, Toronto, ON M5G1L7, Canada.ORCID https://orcid.org/0009-0007-8344-0894
Keegan GuidolinPrincess Margaret Cancer Centre, University Health Network, 101 College Street, PMCRT 5-354, Toronto, ON M5G1L7, Canada.
Lili DingPrincess Margaret Cancer Centre, University Health Network, 101 College Street, PMCRT 5-354, Toronto, ON M5G1L7, Canada.
Yulin MoPrincess Margaret Cancer Centre, University Health Network, 101 College Street, PMCRT 5-354, Toronto, ON M5G1L7, Canada.ORCID https://orcid.org/0009-0006-7716-905X
Ashley QianPrincess Margaret Cancer Centre, University Health Network, 101 College Street, PMCRT 5-354, Toronto, ON M5G1L7, Canada.
Nahyun KwonPrincess Margaret Cancer Centre, University Health Network, 101 College Street, PMCRT 5-354, Toronto, ON M5G1L7, Canada.
Layla PiresDepartment of Biomedical Engineering, Texas A&M University, College Station, Texas 77840, United States.
Brian C WilsonPrincess Margaret Cancer Centre, University Health Network, 101 College Street, PMCRT 5-354, Toronto, ON M5G1L7, Canada.
Ali MakkyUniversité Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 92296 Châtenay-Malabry, France.ORCID https://orcid.org/0000-0002-3807-0886
Juan ChenPrincess Margaret Cancer Centre, University Health Network, 101 College Street, PMCRT 5-354, Toronto, ON M5G1L7, Canada.
Gang ZhengPrincess Margaret Cancer Centre, University Health Network, 101 College Street, PMCRT 5-354, Toronto, ON M5G1L7, Canada.ORCID https://orcid.org/0000-0002-0705-7398

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porphysomes (PS) are self-assembled porphyrin-lipid nanoparticles with intrinsic multifunctionality for cancer theranostics. We recently discovered that incorporating EDTA-conjugated lipids (EDTA-lipids) into lipid nanoparticle formulations significantly enhances intracellular uptake by modulating the cell membrane fluidity. To retain the favorable

Indexed as

Antitumor ImmunityCancerNanoparticlePhotodynamic TherapyPorphyrinPorphysome

Identifiers

PMID41695020
PMCPMC12904080

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.