ArticleCureus2026
Adult-Onset Still's Disease: A Diagnostic Odyssey and Therapeutic Triumph.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adult-onset Still's disease (AOSD) is a rare systemic autoinflammatory disorder defined by quotidian fevers, arthralgia, and marked hyperferritinemia, often mimicking infectious, autoimmune, or malignant conditions. We present a diagnostically challenging and clinically instructive case involving a 34-year-old man with persistent fevers, systemic inflammation, and hepatic dysfunction. Despite extensive investigation, infectious and autoimmune etiologies were excluded. The diagnostic breakthrough emerged upon identification of profound hyperferritinemia (6,900 ng/mL), prompting the diagnostic consideration of AOSD. Initiation of corticosteroid therapy led to rapid symptom resolution and biochemical normalization. This case underscores the vital role of pattern recognition, diagnostic exclusion, and timely immunosuppression in AOSD. We emphasize the importance of early ferritin assessment and highlight regional diagnostic biases, particularly among darker-skinned individuals, in whom rash may be absent or underrecognized.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.