ArticleCureus2026
Hyperlactatemia, Coagulopathy, and Hepatic Injury as Prognostic Markers of Mortality in Pediatric Dengue: A Single-Center Retrospective Cohort Study.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
backgroundSevere dengue has a high mortality rate, especially when identification is delayed. Objective, early laboratory discriminators of mortality could improve triage and resource allocation in pediatric critical care. This study aimed to identify robust admission laboratory discriminators of mortality among children with dengue and to evaluate their individual prognostic performance. METHODOLOGY: We conducted a single-center retrospective observational study of 114 pediatric patients with confirmed dengue infection admitted to the pediatric critical care unit of Tata Main Hospital, Jamshedpur, between June 2023 and December 2023. Admission to the unit followed a uniform institutional protocol based on World Health Organization (WHO) guidelines. Demographic, clinical, and laboratory data (including lactate levels, coagulation profiles, and liver enzymes) were extracted from electronic records. Statistical analyses included the Mann-Whitney U test for continuous variables, Fisher's exact test for categorical variables, Spearman's correlation, and receiver operating characteristic (ROC) analysis.
resultsNon-survivors (
conclusionsHyperlactatemia, coagulopathy, and hepatocellular injury are significantly correlated with mortality in dengue, with lactate and PT-INR demonstrating particularly robust individual discriminative capabilities. These readily available biomarkers may help identify high‑risk patients early, but the proposed cutoffs require prospective multicenter validation before routine integration into dengue management protocols.
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