Evidence map›Paper›PMID 41694683›Full record

ArticleFrontiers in medicine2025

Impact of pneumatic tube vs. bicycle courier transport on platelet aggregation: influence of sex and diabetes.

Anna Hohneck, Elisabeth Kliemank, Simon Bach, Sebastian Brings, Lukas Seebauer, Mani Roshan, Zoltan Kender, Stefan Kopf, Norbert Frey, Markus Zorn and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anna HohneckDepartment of Endocrinology, Diabetology, Metabolism and Clinical Chemistry, Heidelberg University Hospital, Heidelberg, Germany.
Elisabeth KliemankDepartment of Endocrinology, Diabetology, Metabolism and Clinical Chemistry, Heidelberg University Hospital, Heidelberg, Germany.
Simon BachDepartment of Endocrinology, Diabetology, Metabolism and Clinical Chemistry, Heidelberg University Hospital, Heidelberg, Germany.
Sebastian BringsDepartment of Endocrinology, Diabetology, Metabolism and Clinical Chemistry, Heidelberg University Hospital, Heidelberg, Germany.
Lukas SeebauerDepartment of Endocrinology, Diabetology, Metabolism and Clinical Chemistry, Heidelberg University Hospital, Heidelberg, Germany.
Mani RoshanDepartment of Endocrinology, Diabetology, Metabolism and Clinical Chemistry, Heidelberg University Hospital, Heidelberg, Germany.
Zoltan KenderDepartment of Endocrinology, Diabetology, Metabolism and Clinical Chemistry, Heidelberg University Hospital, Heidelberg, Germany.
Stefan KopfDepartment of Endocrinology and Diabetology, University Hospital Schleswig-Holstein, Luebeck, Germany.
Norbert FreyDepartment of Cardiology, Angiology and Pneumology, University of Heidelberg, Heidelberg, Germany.
Markus ZornDepartment of Endocrinology, Diabetology, Metabolism and Clinical Chemistry, Heidelberg University Hospital, Heidelberg, Germany.
Stefan M WoernerDepartment of Endocrinology, Diabetology, Metabolism and Clinical Chemistry, Heidelberg University Hospital, Heidelberg, Germany.
Thomas FlemingDepartment of Endocrinology, Diabetology, Metabolism and Clinical Chemistry, Heidelberg University Hospital, Heidelberg, Germany.
Julia SzendroediDepartment of Endocrinology, Diabetology, Metabolism and Clinical Chemistry, Heidelberg University Hospital, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: Pneumatic tube (PT) transport can impact platelet function, often altering platelet aggregation. Consequently, manual transport is frequently recommended to mitigate preanalytical effects on platelet function tests. However, comparative data between PT and bicycle courier (BC) transport remain limited, and it is unclear whether different agonist pathways or specific patient characteristics, such as sex and diabetes, modify transport-related effects. Methods: In this study, two S-Monovette® 3.2% citrate syringes of whole blood were collected from 96 participants (43 female participants, 53 male participants; median age: 63 years). Samples were transported simultaneously by PT or BC to the Central Laboratory of University Hospital Heidelberg. Platelet function was assessed through light transmission aggregometry (LTA) using five diagnostically established agonists, including ADP, arachidonic acid, ristocetin, collagen, and epinephrine. Results: BC transport was associated with small but statistically significant reductions in platelet aggregation compared with PT for several agonists: ADP (-2.5%, Conclusion: PT transport resulted in minor increases in platelet aggregation compared with BC transport, which are unlikely to be clinically relevant for the majority of patients but may influence interpretation in selected subgroups, particularly in individuals with heightened platelet reactivity or borderline test results. The observed transport-related differences in female patients and individuals with diabetes suggest increased platelet mechanosensitivity in these groups and warrant confirmation in larger, dedicated studies.

Indexed as

bicycle courierdiabetesplatelet functionpneumatic tube systemsex-specific differences

Identifiers

PMID41694683
PMCPMC12902833

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.