ArticlebioRxiv : the preprint server for biology2025
Cell cycle control of cohesion establishment.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
Funding
Abstract
Cohesion between sister chromatids ensures accurate alignment and segregation of chromosomes during cell division. Cohesion establishment requires modification of the SMC3 subunit of cohesin by the ESCO2 acetyltransferase. ESCO2 function relies on interactions between ESCO2 and the DNA replication machinery, but how and whether these interactions are regulated during cell cycle progression is not known. Here we have found that phosphorylation of ESCO2 at serine 75 by cyclin-dependent kinase strongly impacts both interaction of ESCO2 with the replication machinery
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.