Evidence map›Paper›PMID 41694594›Full record

ArticleInternational journal of biological sciences2026

Human umbilical cord mesenchymal stem cell delivery of mitochondria to melanocytes enhances skin repigmentation efficacy in autologous epidermal cell suspension transplantation through the TNFAIP2-TNT system.

Xiaodong Jin, Shishi Xiong, Bo Wang, Qi Wang, Jia Zhang, Zeqian Wang, Yuqi Zhou, Xiaoqi Chen, Tong Wu, Shanshan Gao and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiaodong JinDepartment of Dermatology, Xijing Hospital, Fourth Military Medical University, No. 127 of West Changle Road, Xi'an, Shannxi, 710032, China.
Shishi XiongDepartment of Dermatology, Xijing Hospital, Fourth Military Medical University, No. 127 of West Changle Road, Xi'an, Shannxi, 710032, China.
Bo WangDepartment of Dermatology, Xijing Hospital, Fourth Military Medical University, No. 127 of West Changle Road, Xi'an, Shannxi, 710032, China.
Qi WangDepartment of Dermatology, Xijing Hospital, Fourth Military Medical University, No. 127 of West Changle Road, Xi'an, Shannxi, 710032, China.
Jia ZhangDepartment of Dermatology, Xijing Hospital, Fourth Military Medical University, No. 127 of West Changle Road, Xi'an, Shannxi, 710032, China.
Zeqian WangDepartment of Dermatology, Xijing Hospital, Fourth Military Medical University, No. 127 of West Changle Road, Xi'an, Shannxi, 710032, China.
Yuqi ZhouDepartment of Dermatology, Xijing Hospital, Fourth Military Medical University, No. 127 of West Changle Road, Xi'an, Shannxi, 710032, China.
Xiaoqi ChenDepartment of Dermatology, Xijing Hospital, Fourth Military Medical University, No. 127 of West Changle Road, Xi'an, Shannxi, 710032, China.
Tong WuDepartment of Dermatology, Xijing Hospital, Fourth Military Medical University, No. 127 of West Changle Road, Xi'an, Shannxi, 710032, China.
Shanshan GaoDepartment of Dermatology, Xijing Hospital, Fourth Military Medical University, No. 127 of West Changle Road, Xi'an, Shannxi, 710032, China.
Chenxi ZhangDepartment of Dermatology, Xijing Hospital, Fourth Military Medical University, No. 127 of West Changle Road, Xi'an, Shannxi, 710032, China.
Qing ZhangDepartment of Dermatology, Xijing Hospital, Fourth Military Medical University, No. 127 of West Changle Road, Xi'an, Shannxi, 710032, China.
Yucheng SunDepartment of Dermatology, Xijing Hospital, Fourth Military Medical University, No. 127 of West Changle Road, Xi'an, Shannxi, 710032, China.
Zhe JianDepartment of Dermatology, Xijing Hospital, Fourth Military Medical University, No. 127 of West Changle Road, Xi'an, Shannxi, 710032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autologous epidermal cell suspension (AECS) transplantation is essential for treating large-area depigmenting diseases and some chronic wounds that are refractory to conservative therapy. However, this technique encounters challenges, including limited repigmentation efficacy and high costs, which have hindered its clinical adoption. To enhance the repigmentation efficacy of AECS, our research explored the optimal conditions for preparing suspensions of epidermal cells (ECs). Next, we investigated the functions of melanocytes (MCs) and repigmentation efficacy through co-culturing and co-transplantation of human umbilical cord mesenchymal stem cells (hUCMSCs) with AECS. The addition of hUCMSCs to this system enhanced the proliferation, migration, and melanin synthesis capabilities of the ECs. These findings were validated

Indexed as

Epidermal CellsMelanocytesMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMitochondriaSkin PigmentationUmbilical CordAnimalsCell ProliferationCoculture TechniquesHumansMelaninsMiceMelaninsAutologous epidermal cell suspensionHuman umbilical cord mesenchymal stem cellsmitochondrial transferRepigmentationTNFAIP2-TNT system

Identifiers

PMID41694594
PMCPMC12905636

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.