Evidence map›Paper›PMID 41694589›Full record

ArticleInternational journal of biological sciences2026

Abnormal mechanical load aggravates subchondral bone remodeling and uneven tibial plateau settlement in knee osteoarthritis via activation of osteoblast Piezo1-Ca²⁺-JAK2/STAT3 signaling.

Handi Li, Shuo Zhang, Chen Feng, Fangyan Cheng, Yuanyuan Han, Mengxue Wang, Shuai Zhou, Wenbo Shao, Wenzhong Chen, Jingguo Chen and 3 more

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Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Handi LiDepartment of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Shuo ZhangDepartment of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Chen FengDepartment of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Fangyan ChengDepartment of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Yuanyuan HanDepartment of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Mengxue WangHebei Medical University, Shijiazhuang, China.
Shuai ZhouDepartment of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Wenbo ShaoDepartment of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Wenzhong ChenHebei Medical University, Shijiazhuang, China.
Jingguo ChenDepartment of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Kai LiuHebei Medical University, Shijiazhuang, China.
Yingze ZhangDepartment of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Juan WangDepartment of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanical overload is closely associated with the theory of uneven tibial plateau settlement in knee osteoarthritis (KOA). Excessive mechanical stress leads to abnormal force distribution within the subchondral bone, eventually inducing medial tibial plateau collapse. This process disrupts local biomechanical homeostasis and triggers aberrant bone remodeling. However, the precise molecular basis of subchondral bone remodeling and structural changes in the knee is still not fully understood. In this work, we employed a mouse model of KOA with osteoblast-specific Piezo1 deletion, together with

Indexed as

Bone RemodelingIon ChannelsJanus Kinase 2Osteoarthritis, KneeOsteoblastsSTAT3 Transcription FactorTibiaAnimalsCalciumMaleMiceSignal TransductionStress, MechanicalCalciumIon ChannelsJak2 protein, mouseJanus Kinase 2Piezo1 protein, mouseStat3 protein, mouseSTAT3 Transcription FactorJAK2/STAT3 signalingknee osteoarthritisosteoblastPiezo1subchondral boneuneven tibial plateau settlement

Identifiers

PMID41694589
PMCPMC12905582

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.