ArticleFrontiers in endocrinology2026
Reproductive and obstetric outcomes following frozen embryo transfer: letrozole combined with human menopausal gonadotropin versus hormone replacement cycle.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Background: This study aimed to compare reproductive and obstetric outcomes between frozen embryo transfer (FET) cycles using letrozole combined with human menopausal gonadotropin (HMG) for ovulation induction (OI) and hormone replacement therapy (HRT) for endometrial preparation. Methods: A retrospective cohort study was conducted on 1,880 FET cycles from 2016 to 2024. Cycles were stratified into the OI group ( Results: After adjustment for confounders, no statistically significant difference was observed in the primary outcome of LBR between the OI and HRT groups (OR = 1.145, 95% CI: 0.932-1.407; Conclusions: Adjusted analysis revealed comparable LBR between the OI and HRT protocols. The OI protocol was associated with a lower risk of cesarean section and GDM in the overall population, with exploratory subgroup analyses suggesting potential differential effects in specific patient groups. These findings warrant prospective validation.
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