Trial reportFrontiers in public health2026
Sitz bath with different concentrations of diluted povidone-iodine for prevention of perianal infection in patients with hematological malignancies undergoing chemotherapy: a randomized controlled trial in a tertiary hospital in China.
Trial report in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The incidence of perianal infection in patients with hematologic malignancies undergoing chemotherapy can reach 40-50%. Despite advances in medical technology and improved management strategies, the rate of perianal infection following chemotherapy remains substantial. Currently medicated sitz baths are not widely adopted in clinical practice due to their side effects and limited applicability. Povidone-iodine (PI) is a commonly used clinical broad-spectrum antiseptic, yet its efficacy in preventing perianal infection has not been adequately studied. Therefore, we aimed to evaluate the effect of different concentrations of diluted povidone-iodine in sitz baths on the incidence and severity of perianal infection, and to determine an appropriate concentration that minimizes adverse reactions. Methods: We recruited 180 patients from the Department of Hematology, West China Hospital, Sichuan University, between May 2021 and May 2023. Eligible patients received 14 days of perianal care consisting of either routine cleaning alone or routine cleaning plus sitz baths with povidone-iodine solution. They were randomly assigned to a control group (routine perianal cleaning and care, Results: A total of 171 patients aged 18-80 years undergoing chemotherapy for hematologic malignancies were included. The incidence of perianal infection significantly differed between the control group and both intervention groups with different concentrations (OR = 0.144, ARR = 0.221, 95% CI 0.038-0.054, Conclusions: Both 1:50- and 1:200-diluted povidone-iodine sitz baths are more effective than routine care in preventing perianal infections and can effectively reduce both the incidence and severity of perianal infections. However, the 1:50 dilution was associated with more perianal adverse events (AEs) compared with the 1:200 dilution. Trial Registration: It was registered in the Chinese Clinical Trial Registry (Registration number: ChiCTR 2000041073) on December 17, 2020.
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