Evidence map›Paper›PMID 41694496›Full record

ArticleWorld journal of gastroenterology2026

Gallbladder carcinoma in Brazil: Clinicopathological profile and survival outcomes from a high-volume cancer center.

Fabio Ferrari Makdissi, Lucas Eiki Kawakami, Marina Alessandra Pereira, Jaime Arthur Pirola Kruguer, Gilton Fonseca Marques, Fabricio Ferreira Coelho, José Jukemura, Paulo Herman

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Article in World journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Fabio Ferrari MakdissiDepartment of Gastroenterology, Instituto do Cancer, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 01246000, Brazil. fabio.makdissi@hc.fm.usp.br.
Lucas Eiki KawakamiDepartment of Gastroenterology, Instituto do Cancer, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 01246000, Brazil.
Marina Alessandra PereiraDepartment of Gastroenterology, Instituto do Cancer, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 01246000, Brazil.
Jaime Arthur Pirola KruguerDepartment of Gastroenterology, Instituto do Cancer, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 01246000, Brazil.
Gilton Fonseca MarquesDepartment of Gastroenterology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403900, Brazil.
Fabricio Ferreira CoelhoDepartment of Gastroenterology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403900, Brazil.
José JukemuraDepartment of Gastroenterology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403900, Brazil.
Paulo HermanDepartment of Gastroenterology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403900, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGallbladder cancer (GBC) is the most prevalent malignant tumor of the biliary tract and remains associated with poor survival outcomes due to its aggressive biological behavior and typically late diagnosis. Regional differences in incidence and outcomes emphasize the need for country-specific data. In Brazil such information remains scarce.

aimTo evaluate the clinicopathological characteristics, therapeutic approaches, and survival outcomes of patients with GBC treated at a high-volume cancer center in Brazil.

methodsThis retrospective study analyzed 364 patients with histologically confirmed gallbladder adenocarcinoma treated at a high-volume Brazilian cancer center from 2010 to 2024. Clinical, pathological, and treatment-related variables were analyzed. Patients were stratified into incidental GBC (IGBC) and non-IGBC groups.

resultsThe cohort was predominantly female (78.8%) with a mean age of 62.1 years. Most patients (72.3%) presented with stage IV disease. IGBC accounted for 54.1% of cases and showed significantly improved survival compared with non-IGBC [median overall survival (OS): 18 months

conclusionGBC in Brazil commonly presents at advanced stages, restricting curative options. IGBC is more prevalent and has better outcomes. Radical surgery confers the best prognosis but remains feasible in a minority of patients.

Indexed as

AdenocarcinomaGallbladder NeoplasmsAdultAgedAged, 80 and overBrazilCancer Care FacilitiesCholecystectomyFemaleGallbladderHospitals, High-VolumeHumansIncidental FindingsMaleMiddle AgedNeoplasm StagingAdenocarcinomaBiliary tract neoplasmsBrazilGallbladder neoplasmsIncidental cancerPrognostic factorsSurgical oncologySurvival

Identifiers

PMID41694496
PMCPMC12897961

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.