Evidence map›Paper›PMID 41694494›Full record

ReviewWorld journal of gastroenterology2026

Noninvasive diagnosis of colorectal adenoma: The emerging potential of blood-based biomarkers.

Cen-Yi Qi, Ran Wang, Jia-Wei Wang, Guo-Liang Ye, Ping Yang, Yu-Ping Zhou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cen-Yi QiDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo 315020, Zhejiang Province, China.
Ran WangDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo 315020, Zhejiang Province, China.
Jia-Wei WangDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo 315020, Zhejiang Province, China.
Guo-Liang YeDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo 315020, Zhejiang Province, China.
Ping YangDepartment of Geriatric Medicine, The First Affiliated Hospital of Ningbo University, Ningbo 315020, Zhejiang Province, China.
Yu-Ping ZhouInstitute of Digestive Disease, Institute of Digestive Disease of Ningbo University, Ningbo 315020, Zhejiang Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related death globally. Most CRCs arise from colorectal adenomas (CRAs), particularly advanced adenomas, which are recognized as critical precancerous lesions. Early detection and intervention at the adenoma stage are essential for alleviating the global disease burden of CRC. However, conventional screening methods such as colonoscopy are invasive and have poor compliance, underscoring the urgent need for efficient, noninvasive diagnostic alternatives. Blood-based biomarkers have gained substantial attention because of their accessibility, reproducibility, and potential for early detection. Advances in multiomics technologies including proteomics, metabolomics, transcriptomics, and epigenomics have led to the identification of numerous plasma- and serum-derived biomarkers. These include noncoding RNAs (

Indexed as

AdenomaBiomarkers, TumorColorectal NeoplasmsEarly Detection of CancerColonoscopyHumansLiquid BiopsyMass ScreeningMultiomicsProteomicsBiomarkers, TumorAdvanced adenomaCirculating biomarkersColorectal adenomaColorectal cancerEarly detectionNoninvasive screening

Identifiers

PMID41694494
PMCPMC12898864

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.