ArticleWorld journal of gastroenterology2026
New-onset persistent organ failure predicts adverse outcomes in patients with severe acute pancreatitis.
Article in World journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundOrgan failure (OF) is a frequent and critical feature of severe acute pancreatitis (SAP). However, the association between OF patterns and mortality is still a subject of debate.
aimTo compare the clinical profiles of SAP cases with and without new-onset OF (NOOF) and identify adverse outcome predictors.
methodsWe conducted a retrospective cohort study of patients with SAP at a tertiary referral hospital to assess OF patterns. Based on the observed OF episodes, the cohort was categorized into OF (
resultsSignificant differences were observed between the OF and NOOF groups in clinical severity and adverse outcomes, characterized by prolonged OF, extended organ support, and increased hospital length of stay. Binary logistic regression revealed significant associations with major complications [odds ratio (OR) = 13.2, 95% confidence interval (CI): 2.1-83.5,
conclusionNew-onset persistent OF, particularly multi-OF, substantially increases mortality after multivariable adjustment in patients with SAP, highlighting the need for further investigation.
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