ArticleNutrition research and practice2026
Diallyl disulfide suppresses weight gain, adipogenesis, and matrix metalloproteinases (MMPs) expression in high-fat-diet-induced obese animal model.
Article in Nutrition research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesExcessive adipogenesis and angiogenesis, mediated by matrix metalloproteinases (MMPs), contribute to the development of obesity-related complications. Diallyl disulfide (DADS), an organosulfur compound derived from garlic, has been reported to exhibit anti-obesity properties, but studies on the expression of MMPs as an anti-obesity effect of DADS are limited. This study investigated the potential role of DADS in regulating weight gain, adipogenesis, and MMP expression in mice fed a high-fat diet. MATERIALS/
methodsSix-week-old male C57BL/6N mice were divided into 4 groups: a normal-fat diet (NF), a high-fat diet (HF), a high-fat diet supplemented with 12.5 mg/kg DADS (HFDADS12.5), and a high-fat diet supplemented with 25 mg/kg DADS (HFDADS25) for 14 weeks. This study measured plasma lipid concentrations, glycerol-3-phosphate dehydrogenase (GPDH) activity, mRNA expression of transcription factors related to adipocyte differentiation in the liver, and the mRNA expression and concentrations of MMP-2 and MMP-9 in epididymal adipose tissue. The plasma concentrations of adiponectin and leptin were also measured.
resultsDADS intake significantly reduced the body weight gain and epididymal adipose tissue weight (
conclusionDADS suppressed body weight gain and adipogenesis, potentially by inhibiting MMP-2 and MMP-9 in mice fed a high-fat diet.
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