Evidence map›Paper›PMID 41694460›Full record

ArticleFrontiers in aging neuroscience2025

The effect of hearing ability on dual-task performance following multi-domain training in older adults with mild cognitive impairment: findings from the SYNERGIC trial.

Rachel I Downey, Berkley J Petersen, Niroshica Mohanathas, Jennifer L Campos, Manuel Montero-Odasso, Louis Bherer, M Kathleen Pichora-Fuller, Nick W Bray, Amer M Burhan, Richard Camicioli and 7 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02808676 (SYNchronizing Exercises, Remedies in GaIt and Cognition), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02808676 naterminatednot on this map

SYNchronizing Exercises, Remedies in GaIt and Cognition (SYNERGIC): A Randomized Controlled Double Blind Trial

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2016 to 2020Enrolled175ConditionsMild Cognitive ImpairmentArmsVitamin D3, Exercises (E), Cognitive Training (CT), placebo D3, control cognitive training
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. What's in a name? reframing advanced Parkinson's disease as a multidimensional state.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Rachel I DowneyDepartment of Psychology/Centre for Research in Human Development, Concordia University, Montréal, QC, Canada.
Berkley J PetersenDepartment of Psychology/Centre for Research in Human Development, Concordia University, Montréal, QC, Canada.
Niroshica MohanathasDepartment of Psychology, University of Toronto, Toronto, ON, Canada.
Jennifer L CamposDepartment of Psychology, University of Toronto, Toronto, ON, Canada.
Manuel Montero-OdassoDepartment of Medicine, Division of Geriatric Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Louis BhererDépartement de Médecine, Université de Montréal, Montréal, QC, Canada.
M Kathleen Pichora-FullerDepartment of Psychology, University of Toronto, Toronto, ON, Canada.
Nick W BrayRecovery and Performance Lab, Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Amer M BurhanOntario Shores Centre for Mental Health Sciences, Whitby, ON, Canada.
Richard CamicioliDepartment of Medicine (Neurology), University of Alberta, Edmonton, AB, Canada.
Sarah FraserInterdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada.
Teresa Liu-AmbroseThe Centre for Aging SMART, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.
Maxime LussierCentre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada.
Laura E MiddletonDepartment of Kinesiology and Health Sciences, University of Waterloo, ON, Canada.
Frederico Pieruccini-FariaDepartment of Medicine, Division of Geriatric Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Natalie A PhillipsDepartment of Psychology/Centre for Research in Human Development, Concordia University, Montréal, QC, Canada.
Karen Z H LiDepartment of Psychology/Centre for Research in Human Development, Concordia University, Montréal, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hearing loss is one of the largest potentially modifiable risk factors for dementia and is linked with poor cognitive-motor dual-task performance (e.g., walking while performing a cognitive task). Hearing loss is more prevalent and severe in males, whereas dementia is more prevalent in females. Physical exercise and cognitive interventions appear promising in improving dual-tasking in older adults; however, it is currently unclear whether hearing ability affects training efficacy on dual-task outcomes in older adults with mild cognitive impairment (MCI), and whether sex influences this effect. Objective: The primary aim of this study was to examine whether hearing ability affects dual-task performance at baseline and after training in individuals with MCI, and whether sex further influences these relationships, irrespective of intervention arm. Methods: Secondary data was analysed from 75 participants with MCI ( Results: At baseline, poorer hearing predicted worse dual-task performance, particularly in males. Dual-task gait variability significantly improved following Multi-Domain Training in participants with a greater degree of self-reported hearing complaints. Sex-stratified analyses revealed that females with more hearing complaints improved more across all interventions, while in the Multi-Domain group, males with poorer objective hearing and females with better hearing showed the greatest gains. Additionally, in those with poorer hearing, lower cognitive scores (MoCA) predicted greater improvements after Multi-Domain Training, but a decline after Placebo Training. Conclusion: Hearing ability, sex, and cognitive status appear to interact to influence the effects of exercise and cognitive training on dual-task performance in older adults with MCI. Multi-Domain Training appears particularly beneficial for those with hearing loss (who are male and/or have lower cognitive status), highlighting the need for personalized interventions to preserve function and slow decline in this at-risk population. Clinical trial registration: https://www.clinicaltrials.gov/ct2/show/NCT02808676, NCT02808676.

Indexed as

cognitive trainingdual-taskexercisegaithearing lossmild cognitive impairmentmulti-domain training

Identifiers

PMID41694460
PMCPMC12901436

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.