Evidence map›Paper›PMID 41694419›Full record

ArticleJFMS open reports

Inherent P-glycoprotein deficiency and macrocyclic lactone toxicity in an Australian Maine Coon cat homozygous for

Madeleine L Roberts

Abstract readCase Reports
In one paragraph

Article in JFMS open reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Madeleine L RobertsFaculty of Science, School of Veterinary Science, The University of Sydney, New South Wales, Australia.ORCID https://orcid.org/0009-0002-6722-7691

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Case summary: A 9-month-old castrated male Maine Coon cat developed tongue protrusion, mydriasis, generalised weakness and ataxia after routine application, as per label guidelines, of NexGard Spectra (Boehringer Ingelheim; active ingredients praziquantel 83 g/l, esafoxolaner 12 g/l, eprinomectin 4 g/l). The cat was managed conservatively for suspected macrocyclic lactone toxicity and made a complete recovery over 3 months. Further testing identified the cat was homozygous for Relevance and novel information: This is the first documented case of a cat homozygous for

Indexed as

drug toxicitygeneticsmacrocyclic lactonepersonalised careP-glycoprotein

Identifiers

PMID41694419
PMCPMC12905057

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.