ArticleFrontiers in immunology2026
Cytokines in patients with Posner-Schlossman syndrome.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Characterization of the aqueous humor microbiome in Posner-Schlossman syndrome: an exploratory metagenomic sequencing study.Frontiers in medicine · 2026Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Purpose: To investigate the inflammatory cytokine profiles in the aqueous humor (AH) of patients with Posner-Schlossman syndrome (PSS) and evaluate their correlations with key ophthalmic parameters. Methods: Aqueous humor samples were collected from 31 eyes with PSS, 26 eyes with primary open-angle glaucoma (POAG), and 20 eyes with age-related cataract (ARC, control group) at the Eye and ENT Hospital of Fudan University. A multiplex bead-based flow cytometric immunoassay was performed to quantify the concentrations of interleukins (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-17), tumor necrosis factor-alpha (TNF-α), and interferons (IFN-α, IFN-γ). Simultaneously, the presence of cytomegalovirus (CMV) DNA in PSS samples was assessed by PCR. Clinical data including corneal endothelial cell density, visual acuity, intraocular pressure (IOP), and visual field were also recorded. Results: The AH levels of IL-1β, IL-5, IL-6, IL-8, IL-10, IFN-γ, and TNF-α were significantly elevated in PSS patients compared to controls ( Conclusion: Distinct inflammatory cytokine profiles in the AH of PSS patients suggest a prominent immune response potentially contributing to disease pathogenesis. IL-6 may serve as a biomarker reflecting both inflammation and tissue damage in PSS. Note: CECD, corneal endothelial cell density; RECL, relative decrease in CECD loss between the affected eye and the fellow eye.
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