ReviewFrontiers in immunology2026
The dual roles of ferroptosis in digestive tract tumors: mechanisms, microenvironment regulation, and therapeutic integration with emphasis on immune interactions.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Review
- Programmed cell death and metastatic evolution in breast cancer: the role of anoikis, necroptosis, and ferroptosis.Apoptosis : an international journal on programmed cell death · 2026Review
- Targeting Ferroptosis to Overcome Radioresistance and Enhance Immunotherapy in Colorectal Cancer.Cells · 2026Review
- Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malignant tumors of the digestive tract are a major global health burden, characterized by high incidence and mortality rates, limited treatment options for advanced patients, and poor prognosis. Ferroptosis is an iron-regulated form of cell death driven by lipid peroxide (LPO) accumulation, and it is closely linked to the occurrence and progression of various cancers. Ferroptosis plays a critical role in the proliferation, metastasis, drug resistance, and microenvironment regulation of digestive tract cancer. This article will systematically examine the dual roles of ferroptosis through the core concepts of mechanism analysis, microenvironment regulation, and immune interactions, while exploring the therapeutic potential of targeting ferroptosis in the treatment of gastrointestinal malignancies.
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