Evidence map›Paper›PMID 41694357›Full record

ArticleFrontiers in immunology2026

Case Report: IL2RA (CD25) deficiency: first reported cases in Morocco.

Ahamada Elamine, Ibtihal Benhsaien, Abderrahmane Errami, Yousra Bellarhrib, Zahra Aadam, Mohammed Fahi, Ahmed Aziz Bousfiha, Jalila El Bakkouri, Fatima Ailal

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Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Ahamada ElamineLaboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
Ibtihal BenhsaienLaboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
Abderrahmane ErramiLaboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
Yousra BellarhribDepartment of Pediatric Infectious Diseases and Clinical Immunology, Mother-Child Hospital Abderrahim El Harouchi, Ibn Rochd University Hospital Center, Casablanca, Morocco.
Zahra AadamLaboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
Mohammed FahiLaboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
Ahmed Aziz BousfihaLaboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
Jalila El Bakkouri *Laboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
Fatima Ailal *Laboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD25, the α-chain of the interleukin-2 receptor (IL2RA), is a key component of the IL-2 pathway and is essential for the development and stability of regulatory T cells. Loss-of-function variants in IL2RA cause a very rare autosomal recessive disorder marked by early-onset autoimmunity and recurrent infections with an IPEX-like presentation. We report the first two molecularly confirmed cases of IL2RA (CD25) deficiency in Morocco, each carrying a distinct homozygous mutation. Both patients were born to first-cousin parents and presented in early childhood with recurrent respiratory and gastrointestinal infections, severe failure to thrive, chronic diarrhea with celiac-like enteropathy, and autoimmune manifestations including autoimmune hepatitis, dermatitis, and, in one case, autoimmune thyroiditis. Lymphocyte subset counts and immunoglobulin levels were within or above age-appropriate ranges, but flow cytometry showed a complete absence of CD25 expression on CD4

Indexed as

Interleukin-2 Receptor alpha SubunitChild, PreschoolFemaleHomozygoteHumansInfantMaleMoroccoMutationIL2RA protein, humanInterleukin-2 Receptor alpha SubunitautoimmunityCD25 deficiencyIL2RA deficiencyimmune dysregulationinborn errors of immunityIPEX-like syndromeMoroccoregulatory T cells

Identifiers

PMID41694357
PMCPMC12901503

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