Evidence map›Paper›PMID 41694353›Full record

ReviewFrontiers in immunology2026

Research progress on traditional Chinese medicine-assisted immune checkpoint inhibitors therapy for solid tumors.

Zhipeng Liu, Yijie Xie, Yi He, Keyu Chen, Minjie Zhou, Guodong Ha, Lincheng Duan, Zhengyu Zhao, Dingjun Cai

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhipeng LiuAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Yijie XieAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Yi HeAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Keyu ChenAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Minjie ZhouAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Guodong HaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Lincheng DuanAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Zhengyu ZhaoAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Dingjun CaiAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs) represent a promising approach in tumor therapy. However, when applied to solid tumors-the predominant form of tumors-their efficacy is often constrained by the distinctive tumor microenvironment, yielding low response rates and resistance. Additionally, treatment with ICIs commonly leads to immune-related adverse events (irAEs). These challenges have restricted the broader clinical application of ICIs, underscoring the need for strategies that can enhance their antitumor effects while maintaining a favorable safety profile. Traditional Chinese medicine (TCM) is characterized by holistic regulation and has the therapeutic advantages of multi-level, multi-target and low toxicity. In recent years, it has shown great potential in addressing ICIs-related limitations. This review systematically summarizes current advances in the combined use of TCM and ICIs for solid tumors, aiming to offer new perspectives for incorporating TCM into future cancer treatment strategies.

Indexed as

Drugs, Chinese HerbalImmune Checkpoint InhibitorsMedicine, Chinese TraditionalNeoplasmsAnimalsHumansTumor MicroenvironmentDrugs, Chinese HerbalImmune Checkpoint Inhibitorsdrug deliveryimmune cell infiltrationimmune checkpoint inhibitorssolid tumorstraditional Chinese medicinetumor microenvironment

Identifiers

PMID41694353
PMCPMC12901437

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.