ArticleFrontiers in immunology2026
Vitamin D3 mediates amelioration of ulcerative colitis via the TRPV1-MAPK signaling pathway.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Identification and quantification of putative active constituents of huangqin decoction for ulcerative colitis treatment through the integration of chemical profiling, network pharmacology, and bioinformatics.Frontiers in chemistry · 2026Article
- Integrated Multi-Omics, Machine Learning, and Single-Cell Analysis Provide Insights into Potential Multi-Target Candidate Mechanisms of Combined MAGL11 and Icaritin in Alleviating Imidazole Propionate-Driven Metabolic Intestinal Injury.Drug design, development and therapy · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Ulcerative colitis (UC), known as a complex inflammatory bowel disease, whose pathogenesis has not been fully clarified. The Transient Receptor Potential Vanilloid 1 (TRPV1), along with its downstream Mitogen-Activated Protein Kinase (MAPK) pathway, are vital in regulating inflammation. However, it remains unclear whether vitamin D3 (VD3) exerts a protective effect by regulating this signaling pathway. Methods: This study investigated the TRPV1-MAPK pathway in colon tissues from UC patients and in 3% Dextran Sulfate Sodium (DSS)-induced rodents. In vivo experiments were conducted to evaluate the effects of VD3 intervention on disease phenotype, including body weight, Disease Activity Index (DAI), colon length, histological damage, and epithelial cell apoptosis. The study analyzed gene and protein expression levels of TRPV1 and key molecules in the MAPK pathway, and immunofluorescence co-localization was used to assess TRPV1 expression on macrophages. Serum calcium ion (Ca Results: The TRPV1-MAPK pathway was remarkably upregulated in UC patients and DSS-induced rodents, manifested as upregulated expression levels of TRPV1, phosphorylated p38 (p-p38), and phosphorylated Extracellular Signal-Regulated Kinase (p-ERK). VD3 intervention significantly ameliorated disease phenotype, effectively alleviated weight loss, increased DAI, colon shortening, and tissue damage in mice, and reduced epithelial cell apoptosis. VD3 treatment significantly downregulated both gene transcription and protein expression of TRPV1. Immunofluorescence co-localization confirmed that VD3 reduces TRPV1 expression on macrophages. Alterations in serum Ca Discussion: This study elucidates a protective role of VD3 in UC, whereby it coordinately regulates immune responses and barrier function via the TRPV1-MAPK signaling pathway, providing a novel theoretical and experimental foundation for VD3-based therapy for UC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.