Evidence map›Paper›PMID 41694349›Full record

ReviewFrontiers in immunology2026

Immune cell dynamics and mechanisms of epithelial injury in celiac disease.

Irene Marafini, Silvia Salvatori, Edoardo Troncone, Pasquale De Vico, Elena De Cristofaro, Giovanni Monteleone

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Irene MarafiniDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Silvia SalvatoriGastroenterology Unit, Fondazione Policlinico "Tor Vergata", Rome, Italy.
Edoardo TronconeDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Pasquale De VicoDepartment of Anesthesia, University of Rome "Tor Vergata", Rome, Italy.
Elena De CristofaroGastroenterology Unit, Fondazione Policlinico "Tor Vergata", Rome, Italy.
Giovanni MonteleoneDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite continuous exposure to dietary and microbial antigens, the intestinal mucosa maintains a delicate balance between immune activation and tolerance. This equilibrium depends on the integrity and regulatory functions of the intestinal epithelium and associated immune cells. In the case of celiac disease (CD), gluten ingestion disturbs this equilibrium in people with a genetic predisposition (those with HLA-DQ2 or HLA-DQ8 alleles), and this results in chronic inflammation and villous atrophy. Tissue transglutaminase 2 (TG2) modifies gluten peptides, thus enhancing their affinity for HLA-DQ2/8, with the downstream effect of triggering CD4

Indexed as

Celiac DiseaseIntestinal MucosaAnimalsCytokinesGenetic Predisposition to DiseaseGliadinGlutensGTP-Binding ProteinsHLA-DQ AntigensHumansIntestinal Barrier FunctionProtein Glutamine gamma Glutamyltransferase 2TransglutaminasesCytokinesGliadinGlutensGTP-Binding ProteinsHLA-DQ2 antigenHLA-DQ8 antigenHLA-DQ AntigensProtein Glutamine gamma Glutamyltransferase 2TransglutaminasesCDgliadinHLA-DQ2/DQ8T cellstransglutaminase 2

Identifiers

PMID41694349
PMCPMC12894275

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.