ArticleAlzheimer's & dementia (New York, N. Y.)
Effects of multidomain intervention on cognitive function in older adults with cognitive impairment: A multicenter, four-arm, cluster randomized trial.
Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Effects of multidomain intervention on cognitive function in older adults with cognitive impairment: A multicenter, four-arm, cluster randomized trial.Alzheimer's & dementia (New York, N. Y.)Article
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6 authors.
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Abstract
introductionMultidomain lifestyle-based interventions seem to be effective for cognitive improvement but larger trials are limited, especially in China. This study aims to explore whether multi-domain interventions of Baduanjin exercise, the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet, and relaxation training can improve cognitive function in older adults.
methodsThis is a four-arm cluster randomized trial conducted in 15 centers (counties/districts) in China. A total of 60 communities with 886 older adults with cognitive impairment were randomized to the control group (routine service, RS), and groups B (Baduanjin exercise, plus RS), BM (Baduanjin exercise and MIND diet, plus RS), and BMR (Baduanjin exercise, MIND diet, and relaxation training, plus RS), in a 1:1:1:1 ratio. The intervention lasted for 9 months. The two primary outcomes were an executive function composite and a global cognitive function composite; the secondary outcomes were Mini-Mental State Examination (MMSE) score and six individual tests that comprise the global cognitive function composite.
resultsAmong 886 old adults with cognitive impairment at baseline, 801 and 809 participants were followed for 4.5 months and 9 months, respectively. At the 9-month follow-up, the BMR and BM interventions showed significant effects on executive function (Mean difference in change of composite for BMR vs. Control: 0.26 points [95% CI, 0.11, 0.41],
conclusionA multi-domain comprehensive intervention combining Baduanjin exercise, MIND diet and relaxation training, can significantly improve both executive function and global cognitive function after 9 months in older adults with cognitive impairment. These findings supported the use of these interventions to enhance cognitive function in older adults. Trial Registration: Chinese clinical registry, registration number: ChiCTR2100045375.
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