ArticleFrontiers in nutrition2025
Protein undernutrition alters the colonic bacteriome, disrupts intestinal immune homeostasis, and impairs control of
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Undernutrition is a significant global health issue that exacerbates susceptibility to infectious diseases, including visceral leishmaniasis (VL), caused by Methods: We used BALB/c mice subjected to a low-protein diet and infected with Results: Undernutrition significantly downregulated the mRNA expression of cytokines such as IFN-γ, IL-10, IL-12, and IL-17A in the colon while increasing the colonic luminal levels of proinflammatory cytokines, including TNF-α, CCL5, and IL-17A. The protein-deficient diet also induced dysbiosis, characterized by reduced Discussion: These findings highlight the complex interplay between nutritional status, the microbiota, and host immunity in the progression of VL. Undernutrition exacerbates disease severity through local and systemic immune dysregulation and microbial shifts. Our results support new treatments targeting diet and microbiota to control VL.
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