Evidence map›Paper›PMID 41694287›Full record

ArticleTherapeutic advances in endocrinology and metabolism2026

A case of immune thrombocytopenia aggravated by therapy for hypercortisolism in adrenocortical carcinoma.

Ryo Kaneda, Masanori Murakami, Akiko Hirano, Airi Nakayama, Satoru Uchida, Kazutaka Tsujimoto, Chikara Komiya, Kenji Ikeda, Hiroki Fujiwara, Toshikage Nagao and 3 more

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In one paragraph

Article in Therapeutic advances in endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ryo KanedaDepartment of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-2035-8814
Masanori MurakamiDepartment of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.ORCID https://orcid.org/0000-0002-5541-3502
Akiko HiranoDepartment of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Airi NakayamaDepartment of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Satoru UchidaDepartment of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Kazutaka TsujimotoDepartment of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID https://orcid.org/0009-0008-8150-9461
Chikara KomiyaDepartment of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-5605-7335
Kenji IkedaDepartment of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0003-1380-4983
Hiroki FujiwaraDepartment of Hematology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID https://orcid.org/0009-0007-3756-7659
Toshikage NagaoDepartment of Hematology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-1766-3842
Soichiro YoshidaDepartment of Urology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0003-2757-8083
Yasuhisa FujiiDepartment of Urology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-6761-3229
Tetsuya YamadaDepartment of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cushing's syndrome (CS) is characterized by excessive endogenous cortisol production and necessitates prompt intervention. We report a case of adrenocortical carcinoma (ACC) complicated by CS in a patient with a history of immune thrombocytopenia (ITP). Following treatment with metyrapone and surgical resection aimed at reducing cortisol levels, the patient experienced an ITP relapse. To our knowledge, this is the first report demonstrating the clinical impact of rapid cortisol fluctuations induced by CS treatment on ITP control. The patient required concurrent management with exogenous steroids to maintain platelet counts while correcting hypercortisolism. This case highlights the immunosuppressive role of endogenous cortisol and underscores the need for careful monitoring in patients with coexisting autoimmune disorders undergoing treatment for CS. Awareness of this interaction may inform individualized steroid tapering strategies and improve outcomes in similar clinical scenarios.

Indexed as

adrenocortical carcinomaCushing syndromeimmune thrombocytopenia

Identifiers

PMID41694287
PMCPMC12894640

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.